Description: The OX-86 monoclonal antibody reacts with mouse CD134, also known as OX-40. A member of the TNF receptor superfamily, CD134/OX-40 is a 50 kDa type I membrane glycoprotein expressed by activated mouse T lymphocytes. While rat OX-40 antigen was initially identified as an activation marker on activated rat CD4+ T cells only, the mouse OX-40 is expressed by both activated CD4+ and CD8+ T cells. The interaction of CD134 with OX-40L has been implicated in T cell-dependent humoral response, regulation of primary T cell expansion, survival of T cells, size of the memory T cell pool and regulation of tolerance in the CD4+ T cell compartment.
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