Description: This mCD84.7 monoclonal antibody reacts with mouse CD84, a 64- to 82-kDa member of the SLAM family of Ig receptors. CD84 is a highly glycosylated single transmembrane receptor. Expressed in B and T cells, monocytes, platelets, and thymocytes, this receptor was recently found to also be expressed on Sca-1+c-kit+Lin- mouse bone marrow hematopoietic stem cells. CD84 has been reported to bind itself homophilically to promote IFNγ secretion and act as a costimulatory molecule. Once phosphorylated, the cytoplasmic tail binds signaling lymphocyte activation molecule-associated protein (SAP).
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