Description: The RB6-8C5 monoclonal antibody reacts with mouse Ly-6G, a 21-25 kDa protein also known as the myeloid differentiation antigen Gr-1. A GPI-linked protein, Gr-1 is expressed by the myeloid lineage in a developmentally regulated manner in the bone marrow. While monocytes only express Gr-1 transiently during their bone marrow development, the expression of Gr-1 on bone marrow granulocytes as well as on peripheral neutrophils is a good marker for these populations.
Blocking studies with Ly-6C (clone HK1.4) or RB6-8C5 show no effect against staining with the other clone thereby suggesting that RB6-8C5 does not recognize Ly-6C in resting bone marrow or splenocytes.
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