Description: The MR1 monoclonal antibody reacts with mouse CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). gp39 is expressed transiently by activated T cells and through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, serves a crucial function in T-APC cognate interaction. gp39 interaction with CD40 transduces signals for T-dependent B cell activation and induces B cell cycle entry.
For staining for flow cytometric analysis, it is important to stimulate enriched T cells or enriched CD4 cells (using depletion strategy) prior to staining with MR1.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
