Description: The monoclonal antibody 14F7 recognizes mouse and rat caspase-12. Caspase-12, a 53-60kDa protein, is a cysteine-requiring aspartate protease that plays a role in apoptosis. Expression is ubiquitous and localized to the endoplasmic reticulum. Caspase-12 is believed to mediate apoptosis in response to endoplasmic reticulum (ER) stress rather than Fas mediated apoptosis. Reagents that affect calcium levels, such as A23187, affect oxygen levels, or affect the ER secretory pathway, such as brefeldin-A, all induce ER stress thereby activating procaspase-12 cleavage. Caspase-12 is colocalized to the ER with several proteins that are involved in Alzheimer’s disease including b-amyloid precursor protein (APP) and presenilin. Caspase-9 has been identified as an in vitro substrate of caspase-12. The monoclonal antibody 14F7 recognizes full length caspase-12.
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