Description: The monoclonal antibody 1H11 recognizes human Bid (BH3 interacting domain death agonist), a member of the Bcl-2 family. Bid is a cytoplasmic protein that upon activation via an apoptosis signal is cleaved by caspase-8. Upon cleavage, the active Bid translocates to the mitochondria and binds BAK thereby inducing cytochrome c release and increasing mitochondrial membrane permeability. The 1H11 antibody recognizes the full length protein (24kDa).