Description: CXCL10, also known as IP-10 (Interferon Inducible Protein-10), is a member of the CXC family of chemokines. It is secreted by monocytes, epithelial cells, and endothelial cells in response to IFN gamma or other pro-inflammatory cytokines and stimuli. CXCL10 signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. In addition to its role as a chemoattractant, CXCL10 is also a potent inhibitor of angiogenesis and exhibits antitumor activity.
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