Description:The Fractalkine polyclonal antibody reacts with recombinant and natural mouse CX3CL1 (Fractalkine). The antibody was generated usingE. coli-expressed chemotactic domain of mouse CX3CL1 as an immunogen. CX3CL1, also termed neurotactin or fractalkine, is a membrane-bound CX3C chemokine. The mature protein is part of a 397-amino acid precursor consisting of a chemokine domain (76 amino acids), a mucin stalk of 241 residues, a putative transmembrane domain (18 amino acids), and an intracellular tail of 37 amino acids. Within the chemokine domain the first two cysteine residues are separated by 3 amino acids. CX3CL1 message is found at high concentrations in the brain, and also in kidney, lung and heart. CX3CL1 is chemotactic for monocytes and may play a role in brain inflammation. This antibody has less than 30% cross-reactivity to human and rat Fractalkine. Cross-reactivity to fractalkine of other species has not been determined.
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