Description:The CCL3 polyclonal antibody reacts with both mouse and rat CCL3, also known as MIP-1α (macrophage inflammatory protein-1 alpha). The antibody was generated usingE. coli-expressed amino acids 1-69 of mature rat CCL3 as an immunogen. CCL3 is a 69-amino acid CC chemokine with a molecular weight of 7.9 kDa. CCL3 induces migration of monocytes/macropages, B lymphocytes, activated CD8+T cells, natural killer (NK) cells, and eosinophils. CCL3 also stimulates basophils to release histamine, induces ICAM-1 expression, mast cell degranulation, and production of TNF-α, IL-1 and IL-6. In addition to its proinflammatory activities, CCL3 inhibits the proliferation of hematopoietic stem cellsin vitroandin vivo. Cross-reactivity to CCL3 of other species has not been determined.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
