Description:The rabbit polyclonal antibody reacts with recombinant and natural human and rat CX3CR1; the antibody was generated usingE. coli-expressed human CX3CR1 amino terminal domain as an immunogen. CX3CR1, also termed neurotactini or fractalkine, is a membrane-bound CX3C chemokine. Human CX3CR1, also named V28, was first cloned from human genomic DNA libraries. A G-protein-coupled seven-transmembrane domain receptor, it was recently identified to serve as fractalkine receptor. Human CX3CR1 has been shown to mediate both the adhesive and migratory functions of fractalkine. Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators. Cross reactivity to CX3CR1 of other species has not been determined.
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