IL-8 (1-77) (CXCL8) ANTIBODYPURIFIED 2

产品编号：14-7189-80 品牌：invitrogen 原厂货号：14-7189-80
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

PURIFIED 2

运保温度:

2-8℃

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描述：

Description: The monoclonal antibody N11 reacts specifically with the 77 amino acid form of IL-8 (IL-8₇₇, IL-8_(1-77), CXCL8₇₇) and does not react with the more common 72 amino acid form. Frequently referred to as “endothelial” IL-8, the 77 amino acid form is secreted in cultured leukocytes. The 72 amino acid form is the result of efficient cleavage of an N-terminal pentamer from IL-8₇₇ after secretion. IL-8 is a C-X-C chemokine with potency in neutrophil chemotaxis and activation. IL-8₇₇ has decreased chemotactic activity when compared to IL-8₇₂, but has other specific pro-apoptotic and tumor cell chemotactic activities. IL-8₇₇ has recently been shown to be the major isoform present in premature neonates due to deficiency in serum protease activity that is not seen in term neonates.