Description: The 5B7 monoclonal antibody reacts with mouse Bax (~21 kDa), and does not react with rat and human Bax. 5B7 shows no cross-reaction with Bcl-2 or Bcl-xL proteins. Bcl-2, Bax, and Bcl-xL are members of a protein family that regulates apoptosis; while several family members including Bcl-2 and Bcl-xL inhibit apoptosis, overexpression of Bax promotes programmed cell death. A mouse Bax protein peptide sequence, aa 3-16, was used as immunogen.
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