Description: The C2-10 antibody reacts with mouse and human PARP; the antibody was generated against bovine PARP (Poly-ADP-ribose Polymerase-1). PARP is a 116 kDa nuclear chromatin-associated enzyme that catalyzes the transfer of ADP-ribose units from NAD+ to nuclear proteins such as topoisomerases, histones, and PARP. Following DNA damage, catalytic activity of PARP is increased in nonapoptotic cells. It has been suggested that PARP plays an important role in mediating normal cellular response to DNA damage. PARP is also a target of the protease activity of caspases involved in apoptosis. C2-10 detects both the full-length (116 kDa) and the cleaved (85 kDa) forms of PARP.
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