Description: The polyclonal antibody reacts with human MyD88; the antibody was raised against residues 233-248 of human MyD88 and recognizes human antigens. MyD88, a myeloid differentiation primary response gene, is expressed in a variety of tissues and functions as an adapter molecule in the IL-1 signaling pathway involved in the inflammatory responses induced by cytokines and LPS. MyD88 associates with and recruits IRAK to the IL-1 receptor. Dominant negative mutants of MyD88 attenuate IL-1R-mediated NF-κB activation. MyD88 also functions as a regulator molecule for IL-18 receptor and human Toll receptor family. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to LPS. For applications with mouse MyD88, it is recommended that anti-human/mouse MyD88 (C-terminus) (cat. 14-6223) be used.
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