Description: This rabbit polyclonal antibody reacts with mouse and rat Receptor Interacting Protein (RIP) 3. This 57 kDa Ser/Thr kinase is ubiquitously expressed and resides primarily within the cytoplasm. However, studies have suggested that this protein can shuttle between the nucleus and cytoplasm. Although its kinase domain is similar to that of RIP1 and 2, RIP3 does not possess a death domain or CARD motif. RIP3 binds to and phosphorylates RIP1, resulting in inhibition of RIP1- and TNFR1-mediated NFkB activation. RIP3 mediates programmed necrosis by regulating TNF-induced reactive oxygen species production. Moreover, studies have also identified RIP3 as the molecular switch between TNF-induced apoptosis and necrosis in some cell types.
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