Description: The ATO-2F5 monoclonal antibody reacts with human Stat-1 (Signal Transducer and Activator of transcription-1) and has shown some cross-reactivity to mouse Stat-1. Stat-1 is a ubiquitously expressed transcription factor that resides in the cytoplasm until interferon receptor signaling leads to JAK-mediated phosphorylation. Upon phosphorylation, Stat-1 dimerizes and translocates to the nucleus where it forms the ISGF3 (Interferon-Stimulated Gene Factor 3) complex with Stat-2 and IRF-9. This complex is the main transcriptional activator for interferon signaling.
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