Description: The MFL4 monoclonal antibody reacts with mouse and rat Fas Ligand (CD178), a 40 kDa type II transmembrane glycoprotein. FasL is a member of the TNF family and is expressed by activated T cells. The interaction of FasL with its receptor CD95 induces Fas-mediated killing. It has been reported that the human FasL antigen is cleaved from the surface by matrix metalloproteinases (MMPs), resulting in a 26 kDa soluble form. The degree of sensitivity for the mouse and rat antigens to MMPs has not been reported. MFL4 has been reported in the literature to cross-react with the rat FasL antigen.
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