Description: The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154 kDa α4 subunit and the 130 kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.
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