Description: This monoclonal 9A2 antibody recognizes human and mouse Oct2, a transcription factor that binds conserved octamer DNA motifs within immunoglobulin promoters. The structure of the Oct2 protein consists of an amino terminal glutamine-rich domain, a central POU homeodomain and a carboxy terminal transactivation domain. Predominantly expressed in the nucleus of B cells, Oct2 has also been found in activated T cells and a subset of myeloid cells. Based on knock-out studies, expression is not required for B cell commitment but is required for maturation. In addition to developmental expression, Oct2 has been associated with neoplasm and maybe a useful tool for characterization of DLBCL and classical Hodgkin’s disease.