Description: The RD-41 monoclonal antibody reacts with the murine Rae1δ. Rae-1δ is one of several known murine NKG2D ligands that include RAE-1 molecules (α, β, ε, γ and δ), H60 and MULT-1. Expression of NKG2D ligands is low or absent on normal adult tissues. However, stressed or transformed cells express NKG2D ligands which in turn activates NK cells tumoricidal activity through NKG2D. Until now, the expression of NKG2D ligands has been mainly studied with NKG2D tetramers which recognizes all NKG2D ligands. The RD-41 antibody has been reported to block tetramer staining.
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