Description: The No. 72-1 monoclonal antibody reacts with mouse CD36, which is a 88 kDa member of the class B scavenger receptor family. Murine CD36 was discovered using an expression cloning strategy to identify macrophage receptors that recognized oxidized low-density lipoprotein (oxLDL), but not acetylated low-density lipoprotein (LDL). CD36 is a platelet-membrane glycoprotein, but is also expressed on monocytes/macrophages, granulocytes, B lymphocytes, microvascular endothelial cells, adipocytes, skeletal muscle and dendritic cells. The role of CD36 as a scavenger receptor was confirmed by the CD36-deficient mouse, which was defective in the binding and uptake of oxLDL by peritoneal macrophages. In addition to binding oxLDL, CD36 binds other ligands including TSP-1, anionic phospholipids, apoptotic cells, collagen, Plasmodium falciparum-infected erythrocytes and long-chain fatty acids.
Testing also shows staining on some B cells in the bone marrow in addition to the myeloid cells.
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