Clone REA942 recognizes the mouse CD182 (CXCR2) antigen, which belongs to the class of chemokine receptors specific for CXC chemokines. Chemokine receptors are G-coupled protein receptors (GPCR) with seven-transmembrane domains and consist of an α-subunit and a βγ-complex. Binding of interleukin 8 (IL-8) to CD182 leads to the activation of neutrophil granulocytes. CD182 is also a ligand for CXCL3, GRO/MGSA, and NAP-2.
Additional information: Clone REA942 displays negligible binding to Fc receptors.
Clone REA942 recognizes the mouse CD182 (CXCR2) antigen, which belongs to the class of chemokine receptors specific for CXC chemokines. Chemokine receptors are G-coupled protein receptors (GPCR) with seven-transmembrane domains and consist of an α-subunit and a βγ-complex. Binding of interleukin 8 (IL-8) to CD182 leads to the activation of neutrophil granulocytes. CD182 is also a ligand for CXCL3, GRO/MGSA, and NAP-2.
Additional information: Clone REA942 displays negligible binding to Fc receptors.
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