CD141 (BDCA-3)-APC-Vio770, h, 30 tests

产品编号：130-113-877 品牌：MACS美天旎原厂货号：130-113-877
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描述：

Clone AD5-14H12 recognizes the human CD141 (BDCA-3) antigen which is expressed at high levels on a minor subpopulation of human myeloid dendritic cells (about 0.02% of blood leukocytes). CD141 (BDCA‑3)

high

blood dendritic cells are CD11c

dim

, CD123

–

, CD4

+

, Lin

–

, CD45RO

+

, CD2

–

, and CD16

–

. They express myeloid lineage markers, such as CD13 and CD33, and have a monocytoid morphology. Unlike CD1c (BDCA-1)

+

blood dendritic cells, CD141 (BDCA-3)

high

blood dendritic cells lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. CD141 (BDCA-3) is also present at very low levels on CD14

+

monocytes, granulocytes, CD303 (BDCA‑2)

+

CD304 (BDCA-4/Neuropilin-1)

+

plasmacytoid and CD1c (BDCA-1)

+

myeloid dendritic cells. CD141 (BDCA‑3)

high

CD1c (BDCA-1)

–

myeloid dendritic cells have been designated type-2 myeloid dendritic cells (MDC2s). CD141 is also known as thrombomodulin; thrombomodulin mediates co-agglutination by interaction with thrombin and protein C, though nothing is known about its function on MDC2s.

Alternative Names

THBD, AHUS6, BDCA3, THPH12, THRM, TM

原厂资料：

Clone AD5-14H12 recognizes the human CD141 (BDCA-3) antigen which is expressed at high levels on a minor subpopulation of human myeloid dendritic cells (about 0.02% of blood leukocytes). CD141 (BDCA‑3)

high

blood dendritic cells are CD11c

dim

, CD123

–

, CD4

+

, Lin

–

, CD45RO

+

, CD2

–

, and CD16

–

. They express myeloid lineage markers, such as CD13 and CD33, and have a monocytoid morphology. Unlike CD1c (BDCA-1)

+

blood dendritic cells, CD141 (BDCA-3)

high

blood dendritic cells lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. CD141 (BDCA-3) is also present at very low levels on CD14

+

monocytes, granulocytes, CD303 (BDCA‑2)

+

CD304 (BDCA-4/Neuropilin-1)

+

plasmacytoid and CD1c (BDCA-1)

+

myeloid dendritic cells. CD141 (BDCA‑3)

high

CD1c (BDCA-1)

–

myeloid dendritic cells have been designated type-2 myeloid dendritic cells (MDC2s). CD141 is also known as thrombomodulin; thrombomodulin mediates co-agglutination by interaction with thrombin and protein C, though nothing is known about its function on MDC2s.

Alternative Names

THBD, AHUS6, BDCA3, THPH12, THRM, TM