Clone REA674 recognizes the human CD141 (BDCA-3) antigen, which is expressed at high levels on a minor subpopulation of human myeloid dendritic cells (about 0.02% of blood leukocytes). CD141 (BDCA-3)
high
blood dendritic cells are CD11c
dim
, CD123
–
, CD4
+
, Lin
–
, CD45RO
+
, CD2
–
, and CD16
–
. They express myeloid lineage markers, such as CD13 and CD33, and have a monocytoid morphology. Unlike CD1c (BDCA-1)
+
blood dendritic cells, CD141 (BDCA-3)
high
blood dendritic cells lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. CD141 (BDCA-3) is also present at very low levels on CD14
+
monocytes, granulocytes, CD303 (BDCA‑2)
+
CD304 (BDCA-4/Neuropilin-1)
+
plasmacytoid, and CD1c (BDCA-1)
+
myeloid dendritic cells. CD141 (BDCA-3)
high
CD1c (BDCA-1)
–
myeloid dendritic cells have been designated type-2 myeloid dendritic cells (MDC2s). CD141 is also known as thrombomodulin; thrombomodulin mediates co-agglutination by interaction with thrombin and protein C, though nothing is known about its function on MDC2s.
Additional information: Clone REA674 displays negligible binding to Fc receptors.Alternative Names
Thrombomodulin, Fetomodulin, TM
原厂资料：
Clone REA674 recognizes the human CD141 (BDCA-3) antigen, which is expressed at high levels on a minor subpopulation of human myeloid dendritic cells (about 0.02% of blood leukocytes). CD141 (BDCA-3)
high
blood dendritic cells are CD11c
dim
, CD123
–
, CD4
+
, Lin
–
, CD45RO
+
, CD2
–
, and CD16
–
. They express myeloid lineage markers, such as CD13 and CD33, and have a monocytoid morphology. Unlike CD1c (BDCA-1)
+
blood dendritic cells, CD141 (BDCA-3)
high
blood dendritic cells lack expression of CD2 and Fc receptors such as CD32, CD64, or FcεRI. CD141 (BDCA-3) is also present at very low levels on CD14
+
monocytes, granulocytes, CD303 (BDCA‑2)
+
CD304 (BDCA-4/Neuropilin-1)
+
plasmacytoid, and CD1c (BDCA-1)
+
myeloid dendritic cells. CD141 (BDCA-3)
high
CD1c (BDCA-1)
–
myeloid dendritic cells have been designated type-2 myeloid dendritic cells (MDC2s). CD141 is also known as thrombomodulin; thrombomodulin mediates co-agglutination by interaction with thrombin and protein C, though nothing is known about its function on MDC2s.
Additional information: Clone REA674 displays negligible binding to Fc receptors.Alternative Names
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