Clone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
Additional information: Clone REA739 displays negligible binding to Fc receptors.
Clone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
Additional information: Clone REA739 displays negligible binding to Fc receptors.
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