Clone REA715 recognizes the human CD8b antigen, a single-pass type I membrane protein and member of the immunoglobulin superfamily, also known as T cell surface glycoprotein Lyt-3. The CD8 glycoprotein is expressed by thymocytes, mature T cells, and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex class I antigens and in signal transduction during the course of T cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. Most of peripheral blood CD8
+
T lymphocytes express the CD8a/CD8b heterodimer, while CD8
+
CD16
+
natural killer cells and CD8
+
T cell receptor γ/δ
+
T lymphocytes express only the CD8a/CD8a homodimer. CD8b can therefore be used to selectively bind to CD8
+
T cells while excluding CD8
+
NK cells.
Additional information: Clone REA715 displays negligible binding to Fc receptors.
Alternative Names
CD8 beta chain, CD8 b chain, CD8b
原厂资料：
Clone REA715 recognizes the human CD8b antigen, a single-pass type I membrane protein and member of the immunoglobulin superfamily, also known as T cell surface glycoprotein Lyt-3. The CD8 glycoprotein is expressed by thymocytes, mature T cells, and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex class I antigens and in signal transduction during the course of T cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. Most of peripheral blood CD8
+
T lymphocytes express the CD8a/CD8b heterodimer, while CD8
+
CD16
+
natural killer cells and CD8
+
T cell receptor γ/δ
+
T lymphocytes express only the CD8a/CD8a homodimer. CD8b can therefore be used to selectively bind to CD8
+
T cells while excluding CD8
+
NK cells.
Additional information: Clone REA715 displays negligible binding to Fc receptors.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
