Clone REA626 recognizes the human plexin-B2 antigen, a single-pass type I membrane protein, which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T cell–dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells, and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth, and cell migration. It has several semaphorin ligands including semaphorin-3E, semaphorin-4A, semaphorin-4C, and semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with plexin-B2 on γδ T cells to play a role in the healing process.
Additional information: Clone REA626 displays negligible binding to Fc receptors.
Alternative names
Plxnb2, MM1, Nbla00445, dJ402G11.3
原厂资料：
Clone REA626 recognizes the human plexin-B2 antigen, a single-pass type I membrane protein, which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T cell–dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells, and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth, and cell migration. It has several semaphorin ligands including semaphorin-3E, semaphorin-4A, semaphorin-4C, and semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with plexin-B2 on γδ T cells to play a role in the healing process.
Additional information: Clone REA626 displays negligible binding to Fc receptors.
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