Clone REA618 recognizes the human CD11c antigen, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells. On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)+ CD123low MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)– CD123– MDC2s). CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
Additional information: Clone REA618 displays negligible binding to Fc receptors.
Alternative names
95, CR4, integrin αX, ITGAX, p150
原厂资料：
Clone REA618 recognizes the human CD11c antigen, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells. On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)+ CD123low MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)– CD123– MDC2s). CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
Additional information: Clone REA618 displays negligible binding to Fc receptors.
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