Clone REA542 recognizes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion in vitro. Moreover, it was shown that Sema3E mediates either axonal attraction or repulsion in distinct neuronal populations, depending on the coexpression of neuropilin-1 with plexin-D1. Plexin-D1 expression is generally low in normal adult tissues, it is elevated in endothelial cells of tumor vessels and in cancer cells.
Additional information: Clone REA542 displays negligible binding to Fc receptors.
原厂资料：
Clone REA542 recognizes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion in vitro. Moreover, it was shown that Sema3E mediates either axonal attraction or repulsion in distinct neuronal populations, depending on the coexpression of neuropilin-1 with plexin-D1. Plexin-D1 expression is generally low in normal adult tissues, it is elevated in endothelial cells of tumor vessels and in cancer cells.
Additional information: Clone REA542 displays negligible binding to Fc receptors.
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