This CD11 antibody reacts with human CD11c, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells.
On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)+ CD123low MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)- CD123- MDC2s).
CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
原厂资料:
This CD11 antibody reacts with human CD11c, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells.
On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)+ CD123low MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)- CD123- MDC2s).
CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.