Anti-FoxP3抗体可以特异性地识别FoxP3转录因子的forkhead/winged-helix，如forkhead box P3, scurfin, and JM2。 FoxP3主要在调节性T细胞（亚群）中进行表达，是Treg细胞结构和功能的主要标志和功能因子。
原厂资料：
The Anti-FoxP3 antibody specifically recognizes the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function.1,2 Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.3,4 Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression.
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