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CD1c (BDCA-1)-FITC, human 30 tests

  • 产品编号:130-098-009      品牌:MACS美天旎       原厂货号:130-098-009
  • 产品分类:抗体 > 一抗 > 染料标记抗体
  • 应用分类:
 
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描述:

The clone AD5¬8E7 recognizes human CD1c, also known as BDCA¬1. CD1c is expressed on a major subpopulation of human myeloid dendritic cells (about 0.3% of blood leukocytes). Blood CD1c (BDCA¬1)+ myeloid dendritic cells are CD11chigh, CD123low, CD4+, Lin, CD45RO+, CD2+, CD16, CD141 (BDCA¬3)low, CD303 (BDCA¬2), and CD304 (BDCA-4/Neuropilin¬1). They express myeloid markers (CD13, CD33) as well as Fc receptors (CD32, CD64, FcεRI) and are of monocytoid appearance. A minor proportion of CD1c (BDCA¬1)+ myeloid dendritic cells expresses CD14 and CD11b. In blood, CD1c (BDCA¬1) is also expressed on a subpopulation of CD19+ small resting B lymphocytes. CD1c (BDCA¬1) expression has also been detected on cortical thymocytes, on Langerhans cells, and on CD1a+ dendritic cells generated ex vivo from monocytes or hematopoietic precursor cells. CD1c (BDCA¬1)+ myeloid dendritic cells have been designated as type¬1 myeloid dendritic cells (MDC1s). The CD1c antigen is a member of the CD1 family of proteins that are structurally related to MHC class I proteins and mediate the presentation of non¬peptide antigens to T cells.


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