Description: The antibody reacts with mouse lymphotoxin-beta receptor (LTBR). Northern blot analysis of tissues from adult mice showed that expression levels of LTBR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. The tumor necrosis factor receptor-related protein is the human receptor for the heterotrimer of lymphotoxin-alpha and lymphotoxin-beta. This LT-alpha/LT-beta heterotrimer (LT-α1β2) is assumed to take part in immunologic reactions by cell-cell contact, but does not bind to either TNFR1 (CD120α) or TNFR2 (CD120β). LTBR is expressed by day 7 embryos, so it has been speculated that the LT-alpha/LT-beta receptor system may also have some function in early embryogenesis.
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