Description: This P1D6 monoclonal antibody reacts with human CD49e, which is also known as integrin alpha 5. Integrins constitute a family of cell surface receptors that mediate adhesion between cells or between a cell and the extracellular matrix. These proteins are heterodimers consisting of two distinct subunits, α and β. Integrin alpha 5 is expressed on thymocytes, T cells, monocytes, platelets, as well as early and activated B cells. Integrins are also expressed on non-hematopoietic and cancer cells. Integrin-mediated adhesion is regulated by changes in ligand affinity (or activation), cell shape, and integrin clustering and diffusion. Integrin alpha 5 undergoes post-translational cleavage in its extracellular domain to produce disulfide-linked light and heavy chains that associate with the common beta 1 subunit to form the fibronectin receptor. Studies have demonstrated the involvement of this integrin in cell adhesion, signaling, and apoptosis.
The P1D6 monoclonal antibody has been reported to have blocking activity. Crossblocking studies indicate that P1D6 and eBioSAM-1 recognize a similar epitope.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
