Dynabeads® Mouse T-Activator CD3/CD28 offers a simple method for activation and expansion of T cells that does not require antigen presenting cells or antigen. By combining anti-CD3 and anti-CD28 antibodies on Dynabeads®, the beads will provide both the primary and co-stimulatory signals that are required for activation and expansion of T cells.
Add Dynabeads® for activation, or Dynabeads® plus recombinant IL-2 (rIL-2) for expansion of T cells. All polyclonal T cells, antigen specific T cells, CD4+ T cells, CD8+ T cells and regulatory T (Treg) cells can be expanded. The expanded cells can be further utilized either for subsequent experimental in vitro manipulation, or for adoptive in vivo transfer in mouse models of human disease. Applications may include those for the study of infectious disease, transplantation, autoimmunity and cancer.
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