Human sCD14

• 产品编号：110-01-1000ug      品牌：Peprotech       原厂货号：110-01
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > CD因子及其它细胞表面标记分子
• 应用分类：

描述：

CD14是主要在单核细胞和组织巨噬细胞中表达的细胞表面锚定的糖蛋白。 CD14与MD-2（LY-96）和TLR4形成受体复合物，是细菌脂多糖（LPS）响应的特异性结合信号。该复合物通过MyD88、TIRAP与TRAF6，最终激活NF-κB。 CD14的可溶形式为sCD14，其能够特异性结合胞外空间中的LPS。重组的sCD14是一个331个氨基酸的糖蛋白，含有CD14受体的细胞外部分。重组人sCD14计算出的分子量为35.6 kDa。

原厂资料：

CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Recombinant sCD14 is a 331 amino acid glycoprotein comprising the extracellular portion of the CD14 receptor.

注意事项：

仅用于研究。不适用于诊断或治疗。