Description: This WT31 monoclonal antibody recognizes the human αβ T cell receptor (TCR) complexed with the CD3ε chain. Composed of a 44-kDa α and a 37-kDa β chain, TCR specificity is typically determined by Vα, Jα, Vβ, Dβ, and Jβ gene rearrangement. The TCR is often associated with the CD3 complex, which is composed of at least five polypeptides. The TCR/CD3 complex recognizes and binds to major histocompatibility complex-bound antigen presented by antigen presenting cells such as B cells, dendritic cells, and macrophages. These events lead to T cell activation, resulting in cellular signaling and cytokine production.
The WT31 monoclonal antibody has been reported to induce proliferation of resting T cells, as well as inhibit cytotoxic T cell activity. In addition, some antibodies against CD3 partially inhibit WT31; clone SK7 is recommended for two-color experiments.
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