HUM THROMBOMODULIN- PEPROTECH

• 产品编号：100-58-10ug      品牌：Peprotech1       原厂货号：100-58-10UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > 其它细胞因子和生长因子
• 应用分类：

描述：

血栓调节蛋白（TM，CD141，THBD）是内皮细胞表达的跨膜糖蛋白，可以与凝血因子形成凝血酶复合物。血栓调节蛋白水平降低可与某些心血管疾病，如动脉粥样硬化和血栓形成的发病机理相关。血栓调节蛋白含有575个氨基酸，包括一个18个氨基酸信号序列，497 个氨基酸的胞外结构域，24个氨基酸的跨膜序列，和一个36个氨基酸的胞质区域。重组可溶性人血栓调节蛋白是含有凝血调节蛋白胞外结构域的491个氨基酸的糖蛋白。

原厂资料：

Thrombomodulin (TM, CD141, THBD) is an endothelial cell expressed transmembrane glycoprotein that can form a complex with the coagulation factor, Thrombin. The Thrombomodulin/Thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin and thereby effectively prevents continued coagulation. Reduced levels of Thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of Thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory related diseases. Recombinant soluble Thrombomodulin is a 491 amino acid glycoprotein containing the extracellular domain of Thrombomodulin.

注意事项：

仅用于研究。不适用于诊断或治疗。