Human HB-EGF

• 产品编号：100-47-1000ug      品牌：Peprotech       原厂货号：100-47
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > EGF 表皮生长因子
• 应用分类：

描述：

HB-EGF是通过EGF受体信号的EGF相关的生长因子，能够刺激的平滑肌细胞（SMC）、成纤维细胞、上皮细胞和角质化细胞的增殖。 HB-EGF在许多类型的细胞和组织中表达，包括血管内皮细胞、血管平滑肌、巨噬细胞、骨骼肌细胞、角质细胞和某些肿瘤细胞。 HB-EGF的特异性结合肝素和硫酸肝素蛋白聚糖的能力显著与其它EGF类分子不同。重组人HB-EGF基因编码208个氨基酸的跨膜蛋白，该蛋白被水解切割，以产生可溶性的HB-EGF。重组人HB-EGF的是含有86个氨基酸残基的9.7 kDa蛋白。

原厂资料：

HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.

注意事项：

仅用于研究。不适用于诊断或治疗。