HUMAN SHH- PEPROTECH

产品编号：100-45-500ug 品牌：Peprotech1 原厂货号：100-45-500UG
产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > 其它细胞因子和生长因子
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500 UG

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描述：

Hedgehog（Hh）家族成员是整个动物界有广泛代表性的高度保守的蛋白质。三个已知的哺乳动物的Hh蛋白， Shh、DHH和Ihh结构上相关并且共享一部分相同的氨基酸序列。具生物活性的Hh分子形式是由它们的前体蛋白的自催化裂解得到的。大肠杆菌来源的重组人Shh 是包含176个氨基酸残基的20.0 kDa的蛋白，包括N-末端异亮氨酸- 缬氨酸 - 异亮氨酸取代了天然存在的化学修饰的半胱氨酸残基的序列。

原厂资料：

Members of the Hedgehog (Hh) family are highly conserved proteins which are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93% identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Recombinant E. coli-derived Human Sonic HedgeHog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the natural occurring chemically modified Cys residue.

注意事项：

仅用于研究。不适用于诊断或治疗。