Human HGF

• 产品编号：100-39-1000ug      品牌：Peprotech       原厂货号：100-39
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > HGF 肝细胞生长因子
• 应用分类：

描述：

HGF是一种有效的用于各组织和细胞类型的广谱生长因子。人HGF以线性状态表达，为含697个氨基酸残基多肽前体糖蛋白。这种前体的蛋白水解加工后可产生具有生物学活性的HGF的异源二聚体形式，它通过单个二硫键连接的两条多肽链（α链和β链）保持生物活性。α链由463个氨基酸残基组成，β链由234个氨基酸残基。重组人肝细胞生长因子是由697个氨基酸残基组成的80.0 kDa的多肽。

原厂资料：

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Human HGF is expressed as a linear 697 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 234 amino acid residues.*Manufactured using (BTI-Tn-5B1-4) cells under license from Boyce Thompson Institute for Plant Research, Inc.

注意事项：

仅用于研究。不适用于诊断或治疗。