HUMAN TGF-BETA3- PEPROTECH

• 产品编号：100-36E-10ug      品牌：invitrogen       原厂货号：100-36E-10UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > TGF-beta 转化生长因子beta超家族
• 应用分类：

描述：

TGF-β在哺乳动物中的三个类型TGF-β1、β2和β3，信号通过相同的受体并引发类似的生物学应答。它们是调节细胞增殖、生长、分化，以及合成和细胞外基质沉积的多功能的细胞因子。它们参与各种生理过程，包括胚胎发育，组织重塑和伤口愈合。TGF-β3的生理作用目前还不明确，但其表达模式表明其在某一发育过程中起调控作用。重组人TGF-β2是由一个单一的二硫键连接的两个相同的11​​2个氨基酸的多肽链组成的25.0 kDa的蛋白质。

原厂资料：

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

注意事项：

仅用于研究。不适用于诊断或治疗。