HUMAN TGF-B1- PEPROTECH

• 产品编号：100-21-500ug      品牌：invitrogen       原厂货号：100-21-500UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > TGF-beta 转化生长因子beta超家族
• 应用分类：

描述：

哺乳动物中TGF-β的三个类型TGF-β1、β2和β3，信号通过相同的受体并引发类似的生物学应答。它们是调节细胞增殖、生长和分化，以及合成细胞外基质沉积的多功能细胞因子。它们参与各种生理过程，包括胚胎发育，组织重塑和伤口愈合。它们主要分泌为络合物，存储在细胞表面和细胞外基质中。具有生物活性的TGF-β的释放经历复杂的过程，包括蛋白质水解的复杂过程及像凝血酶敏感蛋白1涉及的诱导构象变化的复杂过程蛋。 TGF-β1是最丰富的类型，由几乎所有类型细胞分泌。它最初被鉴定为具有诱导成纤维细胞表型转化能力，最近的研究表明其涉及到皮肤肿瘤的形成。重组人TGF-β1来源于HEK293细胞，是一个25.0 kDa的蛋白，每个亚基包含112个氨基酸残基，由一个单独的二硫键连接。

原厂资料：

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

注意事项：

仅用于研究。不适用于诊断或治疗。