HUMAN VEGF-D- PEPROTECH

• 产品编号：100-20D-10ug      品牌：invitrogen       原厂货号：100-20D-10UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > VEGF血管内皮生长因子
• 应用分类：

描述：

VEGF-C是VEGF / PDGF家族在结构相关蛋白的成员，是一种有效的血管生成细胞因子。它促进内皮细胞生长，并且还可以影响血管通透性。VEGF-D，在肺、心脏和小肠中高水平表达，在骨骼肌、结肠和胰腺中表达水平则较低。它形成细胞表面相关的，非共价的，二硫键连接的同源二聚体，并且可以结合并激活VEGFR-2（的Flk1）和VEGFR-3（FLT4）受体。在胚胎发生期间，VEGF-D可能在静脉和淋巴血管系统的形成中发挥作用。它还参与了成人淋巴管内皮细胞的生长和维持分化。VEGF-C和VEGF-D是在某些癌症组织中过表达，VEGF-C或VEGF-D水平的升高的与淋巴转移增加相关。重组人VEGF-D是一种非二硫键连接的同型二聚体蛋白，分子量为26.2 kDa，包含两个117个氨基酸的多肽链。由于糖基化，通过SDS-PAGE在非还原条件下在分析，其分子量为20.0-22.0 kDa。

原厂资料：

VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 26.2 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

注意事项：

仅用于研究。不适用于诊断或治疗。