HUMAN VEGF-B- PEPROTECH

• 产品编号：100-20B-500ug      品牌：invitrogen       原厂货号：100-20B-500UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > VEGF血管内皮生长因子
• 应用分类：

描述：

VEGF-B，VEGF家族的成员，是一种有效的促进生长和血管生成的因子。它促进内皮细胞DNA合成，有助于调节血管生成和血管通透性，并抑制某些平滑肌细胞和神经元细胞的凋亡。 VEGF-B表达在除了肝的所有组织中。它能形成与细胞表面相关的二硫键连接的同型二聚体，也能与VEGF-A形成异二聚体。有两种已知的类型，通过选择性剪接形成，被指定为VEGF-B167和VEGF-B186。两种形式都有编码半胱氨酸结构基序的相同的氨基末端序列，但羧基末端结构域不同。VEGF-B的两种类型的信号只通过VEGFR1受体。重组人VEGF-B是一个38.0 kDa的、包含由二硫键连接的两个167个氨基酸残基多肽链形成的同型二聚体蛋白。

原厂资料：

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

注意事项：

仅用于研究。不适用于诊断或治疗。