HUMAN HEREGULINB-1- PEPROTECH

• 产品编号：100-03-500ug      品牌：Peprotech1       原厂货号：100-03-500UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > 其它细胞因子和生长因子
• 应用分类：

描述：

神经调节蛋白是相关基因（NRG1，NRG2，NRG3和NRG4）选择性剪接衍生出的相关的多肽生长因子。目前，超过14种可溶性跨膜蛋白来自NRG1基因。跨膜NRG1同种型的胞外域的蛋白水解加工释放可溶性生长因子。 HRG1-β1的含有Ig结构域和EGF样结构域，对于直接结合到受体酪氨酸激酶erb3和erb4是必需的。进而诱导erb3和erb4与ERB2形成异源二聚体，刺激固有激酶活性，并导致酪氨酸磷酸化。虽然HRG1-β1生物学作用仍不清楚，但已经发现，其促进肠蠕动乳腺癌细胞，很有可能也参与自分泌运动促进因子（AMF）上调表达。重组人调蛋白β1（HRG1-β1）是7.5 kDa的多肽，仅由EGF结构域的调蛋白β1组成（65个氨基酸残基）。

原厂资料：

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of Heregulin-β1 (65 amino acid residues).

注意事项：

仅用于研究。不适用于诊断或治疗。