0600-7104P detects human alpha 1 antichymotrypsin (AACT), a member of the serpin superfamily of serine proteinase inhibitors. AACT has a molecular weight of 68kDa, and functions to protect the lower respiratory tract from proteolytic damage by inhibiting chymotrypsin-like proteinases, and also plays a role in the acute phase response.
Polymorphisms in AACT appear to be tissue specific and influence protease targeting, and mutations in its gene have been implicated in the pathogenesis of Alzheimer's disease (AD). AACT levels are elevated in the cerebrospinal fluid of AD patients and elevated levels are also associated with AD severity.
Application
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visitwww.abdserotec.com/protocols.
Application Name
Yes
No
Not Determined
Suggested Dilution
ELISA
1/100 - 1/1000
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.
Antiserum Preparation
Antisera to alpha 1 antichymotrypsin were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
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