羧苄青霉素钠Carbenicillin Disodium Salt

• 产品编号：02195092.2      品牌：MP       原厂货号：02195092.2
• 产品分类：细胞,细胞培养与转染试剂 > 抗生素和抗真菌剂 > β-内酰胺类抗生素
• 应用分类：细胞培养产品与服务 > 哺乳动物细胞培养 > 细胞培养用抗生素 > Carbenicillin羧苄青霉素

描述：

[2S-(2.a,5.a,6.b)]-6-[(Carboxyphenylacetyl) amino]- 3,3-dimethyl- 7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid, disodium salt；a-Carboxybenzylpenicillin； BRL-2064；penicillanic acid

Description: Semi-synthetic antibiotic related to penicillin. It is a benzyl penicillin derivative with substitution of a-carboxyl group n the benzyl side chain. The product interferes with final cell wall synthesis of susceptible bacteria. It is completely ionized in the blood. Carbencillin disodium is about 50% reversibly protein bound in plasma and its tissue distribution is similar to other penicillins.

Though Carbencillin disodium has substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal effect.

In vitro studies have demonstrated the susceptibility of most strains of the following organisms:

Staphylococcus aureus (non-penicillinase producing)	Enterobacter speciesProteus mirabilis
Staphylococcus epidermidis	Morganella morganii (formerly Proteus morganii)
Streptococcus pneumoniae	Providencia rettgeri (formerly Proteus rettgeri)
Beta-hemolytic Streptococci	Anaerobic bacteria, including:
Streptococcus faecalis	Bacteriodes species
Proteus vulgaris	Peptostreptococcus species
Escherichia coli	Peptococcus species
Salmonella species	Clostridium species
Pseudomonas aeruginosa	Fusobacterium species
Hemophilus influenzae
Neisseria species

In vitro synergism between Carbencillin disodium and aminoglycosides in certain strains of Pseudomonas aeruginosa has been demonstrated.

Some of the pathogenic strains of such microorganisms as Herellea, Mima, Citrobacter, and Serratia have shown susceptibility to Carbencillin disodium.

[6S-(2a,5a,6b)]-6-(羧基苯基-乙酰氨基)-3,3-二甲基-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸二钠盐；a-羰苄青霉素二钠；卡比西林

用途：抗生素；生物碱；医药中间体

原厂资料：

注意事项：

Resistance: Most Klebsiella species and some Serratia species are usually resistant to the action of Carbencillin disodium. Some strains of Pseudomonas have developed resistance to Carbencillin disodium fairly rapidly.
Carbencillin disodium is not stable in the presence of penicillinase producing bacteria.

General Usage: 105 units/liter (5 - 50 ug/ml) in cell culture; approximately 200 mg/kg in vivo. It is typically stable in media at 37°C for approximately 3 days.