Cell Culture Reagent
Not less than 4,800 units/mg.
Slightly soluble in H2O, slightly soluble in alcohol. Light tan powder.
Description: Nystatin is an antifungal antibiotic obtained from Streptomyces noursei. It is known to be a mixture, but the composition has not been completely elucidated. Nystatin A is closely related to amphotericin B. Each is a macrocyclic lactone containing a ketal ring, an all-trans polyene system, and a mycosamine (3-amino-3-deoxyrhamnose) moiety.
Nystatin probably acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components. It is absorbed very sparingly following oral administration. Most of the orally administered nystatin is passed unchanged in the stool.
Stock suspension in water (50 mg/ml) can be aliquoted and frozen at -20°C for up to approximately 3 to 4 months. Suspensions are stable at 37°C for up to 3 days