氨苄青霉素钠Ampicillin Sodium Salt

产品编号：0219452605 品牌：MP 原厂货号：0219452605
产品分类：细胞,细胞培养与转染试剂 > 抗生素和抗真菌剂 > β-内酰胺类抗生素
应用分类：细胞培养产品与服务 > 哺乳动物细胞培养 > 细胞培养用抗生素 > Ampicillin氨苄青霉素

包装：

5 g

运保温度:

2-8°C

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描述：

Sodium Salt
γ-Irradiated
Molecular Biology Reagent
Inhibits cell wall biosynthesis.

氨苄青霉素作用：药品为广谱半合成青霉素，毒性极低。抗菌谱与青霉素相似，对青霉素敏感的细菌效力较低，对草绿色链球菌的抗菌作用与青霉素相仿或略强。对白喉杆菌、破伤风杆菌和放线菌其效能基本和青霉素相同。对肠球菌及李斯特菌的作用则优于苄青霉素。对耐药葡萄球菌及其它能产生青霉素酶的细菌均无抗菌作用。对革兰阴性菌有效，但易产生耐药性。

药品主要用于敏感菌所致的泌尿系统、呼吸系统、胆道、肠道感染以及脑膜炎、心内膜炎等。

主要用于伤寒、副伤寒的治疗；也用于泌尿道、呼吸道感染。

Structure:

Molecular Formula: C₁₆H₁₈N₃O₄SNa

Molecular Weight: 371.4

CAS # 69-52-3

Synonyms: D[-]-a-Aminobenzylpenicillin; 6-[D(-)-a-Aminophenylacetamido]penicillanic acid

Physical Description: White to off-white powder

Ampicillin rapidly loses activity when stored above a pH of 7.0.^4,5,11 Optimal conditions for storage are at +4°C, pH 3.8 to 5. At these conditions the solutions will retain more than 90% activity for approximately one week. Buffer compositions may also effect stability: Optimally Tris buffers should have a pH of approximately 5, citrate buffers at 7, acetate buffers at 6.^4,5

Autoclaving solutions of ampicillin will destroy activity. Solutions can be sterilized by filtration (0.22 um filter) and stored frozen (-20°C or below). Frozen solutions can be stored for up to 3 months.

pKa Values (at 25°C):¹²

Description: Ampicillin is a semi-synthetic derivative of penicillin, active as a broad-spectrum antibiotic. It is inactivated by beta-lactamases and for this reason a beta-lactamase inhibitor should be considered when using ampicillin. Against gram-positive bacteria, ampicillin has a similar mode of action as benzylpenicillin; against gram-negative bacteria, it has a similar mode of action as chloramphenicol and tetracyclines. In E. coli it inhibits cell wall synthesis.¹⁸

Also described for the use of inhancing luminol chemiluminescence.¹⁵

Suggested Effective Concentrations: 100 mg/liter for both gram positive and gram negative bacteria. It is typically stable in media at 37°C for approximately 3 days.²⁶

Availability:

Catalog Number	Description	Size
190148	Ampicillin, sodium salt	5 g 25 g 100g
194199	Ampicillin, sodium salt, gamma-irradiated, molecular biology reagent	20 mg 50 mg
194526	Ampicillin, sodium salt, cell culture reagent	5 g 25 g 100 g

Solubility: Soluble in water (50 mg/ml); soluble in 1 M Ammonium Hydroxide, dilute acids or bases¹²; practically insoluble in alcohol, chloroform, ether and fixed oils.